BMS-1001 Property

Boiling point:

801.2±65.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 50 mg/mL (84.08 mM);Ethanol: Insoluble

pka

2.08±0.10(Predicted)

Water Solubility 

Water: Insoluble

Hazard and Precautionary Statements (GHS)

BMS-1001 Chemical Properties,Usage,Production

Uses

BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction (IC50: 2.25 nM in a homogeneous time-resolved fluorescence binding assay).

Biological Activity

BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. It attenuates the inhibitory effect of soluble PD-L1 on T cell receptor-mediated T lymphocyte activation.

target

Target	Value
PD-1/PD-L1 (Cell-free assay)	253 nM(EC50)